tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperazine-1-carboxylate(CAS: 940284-98-0)

tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperazine-1-carboxylate is a white crystalline solid with a molecular weight of approximately 501.67 g/mol. It has good solubility in organic solvents like DMSO and poor solubility in water. This compound is chemically stable under normal conditions but can react with acids and bases. It is used in various organic reactions due to its boron-containing moiety.

tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperazine-1-carboxylate is synthesized via a Sonogashira coupling reaction between tert-butyl 4-piperazinecarboxylate and 5-bromopyrimidine, in the presence of a palladium catalyst and a base such as sodium carbonate. The reaction typically proceeds with a high yield and good selectivity.

tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperazine-1-carboxylate is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds. It is also utilized in the development of new materials such as polymers and semiconductors, where its functional groups provide versatile reactivity.

When handling tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)piperazine-1-carboxylate, it is important to use personal protective equipment (PPE) such as gloves and goggles. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully, and the substance should be stored in a cool, dry place, away from heat sources and incompatible materials. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.