N-Methoxy-N-methyl-5-pyrimidinecarboxamide(CAS: 823189-68-0)

N-Methoxy-N-methyl-5-pyrimidinecarboxamide is a crystalline solid with a molecular weight of approximately 227.19 g/mol. It has a solubility of around 1.5 g/L in water and is poorly soluble in common organic solvents. Chemically, it is stable under normal conditions but can react with strong acids and bases. It has a pKa of about 7.3, indicating moderate basicity.

N-Methoxy-N-methyl-5-pyrimidinecarboxamide can be synthesized via the reaction of 5-chloropyrimidine-2,4-dicarboxylic acid with methylamine and methanol, using sodium hydroxide as a catalyst. The process yields a high purity product with a yield of approximately 85%. Additional purification steps such as recrystallization may be required to achieve the desired purity.

N-Methoxy-N-methyl-5-pyrimidinecarboxamide is used in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients. It also has potential applications in the polymer industry for the modification of polymer properties, and in the development of new sensors and semiconductors.

When handling N-Methoxy-N-methyl-5-pyrimidinecarboxamide, it is important to use gloves, goggles, and a lab coat to prevent skin and eye contact. It should be stored in a cool, dry place away from strong acids and bases. In case of spill, it should be cleaned up immediately under a fume hood, and the Material Safety Data Sheet (MSDS) should be consulted for specific emergency procedures.