2-(4-Fluorophenyl)-1,3-oxazole(CAS: 885268-39-3)

2-(4-Fluorophenyl)-1,3-oxazole (CAS: 885268-39-3) is a colorless crystalline solid with a molecular weight of approximately 181.14 g/mol. It has a low solubility in water (0.013 g/100 mL at 25°C) but is more soluble in organic solvents like ethanol and acetonitrile. This compound exhibits good stability under normal conditions but is reactive towards strong acids and bases. It can be used in the synthesis of various pharmaceutical intermediates and other organic compounds.

2-(4-Fluorophenyl)-1,3-oxazole can be synthesized via a multistep process, often starting with 4-fluorophenyl isothiocyanate and then reacting it with an appropriate aldehyde or ketone in the presence of a base. Common methods include the Wittig reaction or the Pinnick oxidation. The yield is generally around 65-80%, and the reaction is highly selective, making it an efficient route for the compound's synthesis.

2-(4-Fluorophenyl)-1,3-oxazole (CAS: 885268-39-3) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs, particularly those targeting inflammatory and autoimmune diseases. It also finds applications in the production of certain dyes and in the development of sensors for detecting organic compounds. Its use in semiconductor manufacturing is limited but is explored for specific applications requiring organic materials.

Handling 2-(4-Fluorophenyl)-1,3-oxazole (CAS: 885268-39-3) requires caution due to its reactivity towards strong acids and bases. Protective equipment such as gloves, goggles, and lab coat should always be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. In the case of a spill, immediately clean up with appropriate absorbent material and dispose of it according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.