4-Bromo-3-hydroxy-2-naphthoic acid(CAS: 2208-15-3)

4-Bromo-3-hydroxy-2-naphthoic acid is a crystalline solid with a molecular weight of approximately 265.03 g/mol. It has a solubility of about 0.5 g/100 mL in water at 25°C. The compound is relatively stable but can react with bases to form sodium salts. It is insoluble in organic solvents like ethanol and acetone but soluble in dimethylformamide (DMF).

4-Bromo-3-hydroxy-2-naphthoic acid is typically synthesized through bromination of 3-hydroxy-2-naphthoic acid followed by purification. Common methods include the use of N-bromosuccinimide (NBS) in an inert solvent like dichloromethane at room temperature. The reaction is selective and yields a high percentage of the desired brominated product.

4-Bromo-3-hydroxy-2-naphthoic acid is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the production of functional materials, such as polymers and sensors, due to its unique chemical properties. Additionally, it has applications in the semiconductor industry for the preparation of photoresists and other electronic materials.

When handling 4-Bromo-3-hydroxy-2-naphthoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a fume hood to minimize inhalation hazards. If a spill occurs, it should be contained and disposed of according to local hazardous waste regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.