6-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one(CAS: 676515-34-7)

6-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one is a solid with a crystalline form. Its molecular weight is approximately 251.04 g/mol. The compound has low aqueous solubility, around 0.01 mg/mL in water. It is known for its reactivity, particularly towards nucleophiles, and can undergo substitution reactions at the bromine atom.

6-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one can be synthesized via bromination of 2,3-dihydro-1,8-naphthyridin-4(1H)-one. The bromination can be accomplished using N-bromosuccinimide (NBS) in the presence of a suitable radical initiator under UV light or peroxide. The yield is typically around 80-85%, and the reaction is selective towards bromination.

6-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one finds application in the pharmaceutical industry for the synthesis of various bioactive compounds. It is also used in the polymer industry for the modification of polymers and in the electronic industry for the development of organic semiconductors and sensors.

When handling 6-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be stored in a fume hood to avoid inhalation. In case of a spill, immediately clean up using appropriate absorbents, and consult the Safety Data Sheet (SDS) for further instructions.