2,3-Difluoro-4-methoxybenzonitrile(CAS: 256417-12-6)

2,3-Difluoro-4-methoxybenzonitrile is a colorless solid with a melting point of 54-55°C. Its molecular weight is 198.08 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles and electrophiles. It is used as an intermediate in various synthetic pathways and exhibits good reactivity in electrophilic aromatic substitution reactions.

2,3-Difluoro-4-methoxybenzonitrile is commonly synthesized via the reaction of 4-methoxybenzonitrile with fluorine gas under anhydrous conditions, catalyzed by a suitable fluorinating agent such as tetrafluoroethylene. The process provides good yield and selectivity for the desired product. Other methods include the use of direct fluorination or sequential fluorination and methoxylation reactions.

2,3-Difluoro-4-methoxybenzonitrile (CAS: 256417-12-6) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer or precursor. Additionally, it is utilized in the development of sensors and semiconductors due to its specific chemical and physical properties.

When handling 2,3-Difluoro-4-methoxybenzonitrile (CAS: 256417-12-6), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure work is conducted in a well-ventilated area or a fume hood. Spills should be handled with caution and cleaned up using appropriate methods. Always consult the Safety Data Sheet (SDS) for detailed information on safe handling and emergency procedures.