4-fluoro-3-(4-piperidinyl)-1,2-Benzisoxazole(CAS: 95742-20-4)

4-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole is a white to off-white crystalline solid with a molecular weight of approximately 288.25 g/mol. It is soluble in solvents like dimethylformamide (DMF) and methanol. Chemically, it is known for its stability and reactivity in various chemical transformations, such as nucleophilic substitution and condensation reactions.

4-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole is typically synthesized by the condensation of 4-fluorobenzisoxazole with 4-piperidone in the presence of a catalyst such as p-toluenesulfonic acid (p-TSA). The reaction is optimized for high yield and selectivity, often exceeding 90%.

4-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole is primarily used in the pharmaceutical industry for the development of drugs with potential anti-inflammatory and anti-cancer properties. It also has applications in sensor technology and the synthesis of other organic compounds.

When handling 4-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, ensure the use of appropriate personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. Work in a well-ventilated fume hood to minimize inhalation risks. In case of spills, immediately clean up using appropriate absorbent materials and follow the safety data sheet (SDS) for disposal instructions.