4-(2'-Bromomethyl)-1,3-dihydro-2H-indole-2-one(CAS: 120427-96-5)

4-(2'-Bromomethyl)-1,3-dihydro-2H-indole-2-one is a crystalline solid with a molecular weight of approximately 264.12 g/mol. It has limited water solubility but is soluble in organic solvents such as dichloromethane and dimethylformamide. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is also susceptible to degradation under basic conditions.

4-(2'-Bromomethyl)-1,3-dihydro-2H-indole-2-one can be synthesized through a bromination reaction of indole using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The reaction involves the introduction of a bromomethyl group onto the indole ring, leading to a high yield of the desired product.

4-(2'-Bromomethyl)-1,3-dihydro-2H-indole-2-one is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain biologically active compounds. It may also find applications in the production of functional materials and sensors due to its chemical reactivity and functional groups.

When handling 4-(2'-Bromomethyl)-1,3-dihydro-2H-indole-2-one, it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be handled by appropriate absorbent materials and disposed of according to waste management protocols. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.