2-(tert-Butyl)-6-chloro-N-methoxy-N-methylbenzo[d]oxazole-7-sulfonamide(CAS: 1206896-20-9)

2-(tert-Butyl)-6-chloro-N-methoxy-N-methylbenzo[d]oxazole-7-sulfonamide is a crystalline compound with a molecular weight of approximately 428.23 g/mol. It has a low solubility in water but is soluble in organic solvents such as methanol and acetonitrile. The compound is moderately reactive with bases and can undergo hydrolysis under basic conditions. Its chemical stability is generally good, but it should be stored in a cool, dry place away from moisture and strong acids.

2-(tert-Butyl)-6-chloro-N-methoxy-N-methylbenzo[d]oxazole-7-sulfonamide is typically synthesized through a multi-step process involving chlorination of benzo[d]oxazole, followed by methylation and methoximation. This synthesis requires careful control of reaction conditions to ensure high selectivity and yield. Commonly used catalysts include organometallic reagents like tin(II) chloride, and the reaction is usually carried out in anhydrous conditions to minimize side reactions.

2-(tert-Butyl)-6-chloro-N-methoxy-N-methylbenzo[d]oxazole-7-sulfonamide is primarily used in the pharmaceutical industry for the development of new drugs. Its unique chemical structure makes it a valuable intermediate in the synthesis of various bioactive compounds. Additionally, it has potential applications in the polymer industry for the development of novel materials with specific chemical properties. Some researchers are also exploring its use in sensor technologies and as a component in semiconductor devices.

When handling 2-(tert-Butyl)-6-chloro-N-methoxy-N-methylbenzo[d]oxazole-7-sulfonamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin and eye exposure. This compound should be stored in a fume hood and away from strong acids and bases to prevent unwanted reactions. In the event of a spill, it is recommended to use appropriate spill cleanup procedures and dispose of the waste in compliance with local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.