1-(2,6-Difluorobenzyl)piperazine(CAS: 874774-61-5)

1-(2,6-Difluorobenzyl)piperazine is a colorless to white crystalline solid. Its molecular weight is approximately 266.21 g/mol. It is slightly soluble in water but has good solubility in organic solvents like dichloromethane and ethanol. The compound is relatively stable but reacts with strong acids and bases. It has a melting point of around 110-112°C and a boiling point of about 300°C under reduced pressure.

1-(2,6-Difluorobenzyl)piperazine can be synthesized through the reaction of 2,6-difluorobenzyl bromide with piperazine in the presence of a base such as potassium carbonate. The reaction typically proceeds with high selectivity and yields up to 90% of the desired product. The process involves stirring the mixture at room temperature for several hours, followed by purification through column chromatography.

1-(2,6-Difluorobenzyl)piperazine is primarily used in the pharmaceutical and sensor industries. It serves as a precursor in the synthesis of various pharmaceutical compounds due to its functional groups. Additionally, it can be used in the development of gas sensors for detecting specific chemicals in industrial applications.

When handling 1-(2,6-Difluorobenzyl)piperazine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin contact and inhalation. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be contained and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal procedures.