5-(Hydroxymethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS: 93185-31-0)

5-(Hydroxymethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is a crystalline solid with a molecular weight of approximately 162.02 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. This compound is reactive and can participate in nucleophilic substitution reactions. It may also undergo hydrolysis under basic conditions.

5-(Hydroxymethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is commonly synthesized via the condensation of 2-thiohydantoin with an α-hydroxy aldehyde in the presence of a suitable base. The reaction typically involves a selectivity for the α-position and yields around 85-90%.

5-(Hydroxymethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is used in the pharmaceutical industry for the development of certain drugs due to its biological activity. It is also of interest in the chemical industry for the synthesis of polymers and in sensor technology for its chemical reactivity.

When handling 5-(Hydroxymethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Store it in a dry, well-ventilated area away from incompatible materials and heat sources. Spills should be handled according to the Material Safety Data Sheet (MSDS) and local regulations. Ensure proper fume hood use during handling to minimize exposure risk.