3-(Bromomethyl)tetrahydro-2H-pyran(CAS: 116131-44-3)

3-(Bromomethyl)tetrahydro-2H-pyran is a colorless liquid with a molecular weight of 199.01 g/mol. It has a boiling point of 148-150°C and a melting point of -25°C. This compound is moderately soluble in water but highly soluble in organic solvents. It is reactive towards nucleophiles and can undergo substitution reactions.

3-(Bromomethyl)tetrahydro-2H-pyran is typically synthesized from tetrahydro-2H-pyran using N-bromosuccinimide (NBS) in the presence of a suitable organic solvent. The reaction involves bromination followed by migration of the bromine to the methylene group, yielding the desired product with high selectivity and yield.

3-(Bromomethyl)tetrahydro-2H-pyran is used in pharmaceuticals for the synthesis of bioactive molecules, in polymers as a monomer for functional polymers, and in sensors for detecting specific chemical species. It is also utilized in the production of semiconductors due to its stability and reactivity.

When handling 3-(Bromomethyl)tetrahydro-2H-pyran, proper personal protective equipment (PPE) such as gloves and goggles should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.