5-Chloro-1H-pyrazole-3-carboxylic acid(CAS: 881668-70-8)

5-Chloro-1H-pyrazole-3-carboxylic acid is a white crystalline solid with a molecular weight of approximately 170.01 g/mol. It has a moderate solubility in water (0.1 g/100 mL at 20°C). This compound is relatively stable under normal conditions but can react with strong bases to form salts. It shows weak acidity due to the carboxylic acid group.

5-Chloro-1H-pyrazole-3-carboxylic acid is typically synthesized via a multi-step reaction starting from pyrazole. The initial step involves the chlorination of pyrazole, followed by the condensation of the resulting intermediate with acetic anhydride. This process requires careful control of reaction conditions and the use of appropriate catalysts to achieve high selectivity and yield.

5-Chloro-1H-pyrazole-3-carboxylic acid is used in the pharmaceutical industry as an intermediate for drug synthesis. It also has applications in sensor technology, where its functional groups can be utilized to create sensitive detection systems. Additionally, it is explored in the electronics industry for its potential use in semiconductor materials.

When handling 5-Chloro-1H-pyrazole-3-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and ignition sources. In case of a spill, it should be contained and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.