4-(3-Carbamimidoylguanidino)benzoic acid(CAS: 22817-15-8)

4-(3-Carbamimidoylguanidino)benzoic acid is a crystalline solid at room temperature. Its molecular weight is approximately 251.28 g/mol. The compound is slightly soluble in water and organic solvents. It is reactive towards acids and bases, showing good reactivity in amidation reactions. The compound has a pKa of about 2.5, indicating acidic behavior.

4-(3-Carbamimidoylguanidino)benzoic acid is typically synthesized by the amidation of 4-benzoic acid with 3-carbamoylguanidine in the presence of a catalyst such as 4-(dimethylamino)pyridine or dicyclohexylcarbodiimide. The reaction is typically carried out in an inert solvent like dichloromethane under anhydrous conditions to achieve high yield and selectivity.

4-(3-Carbamimidoylguanidino)benzoic acid is used in the pharmaceutical industry for the development of certain drugs. It is also employed in the production of sensors and as a precursor in the synthesis of other compounds. Additionally, it has applications in the polymer industry for the modification of polymer properties.

When handling 4-(3-Carbamimidoylguanidino)benzoic acid, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The substance should be stored in a fume hood or an enclosed container to minimize exposure. In the event of a spill, it is recommended to use appropriate spill cleanup materials and follow safety data sheet (SDS) guidelines for disposal. Always work with this compound under proper laboratory safety protocols.