4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline(CAS: 87170-48-7)

4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline is a crystalline solid with a molecular weight of approximately 417.01 g/mol. It has a low water solubility of around 0.003 g/L. The compound is highly reactive, particularly with nucleophiles and bases due to its electron-withdrawing groups. It is stable under normal conditions but should be stored in a cool, dry place away from strong oxidizing agents.

4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline is typically synthesized via a multi-step process involving the coupling of 3-chloro-5-(trifluoromethyl)pyridine with 4-chloro-3-hydroxyaniline. The reaction uses a palladium catalyst in the presence of a base. The yield is around 70-75%, with high selectivity towards the desired product. This synthesis requires controlled conditions and proper handling of reagents.

4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline is primarily used in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients (APIs). It is also utilized in the production of organic semiconductors and as a precursor in the development of sensors and polymer materials.

When handling 4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline, it is crucial to use appropriate personal protective equipment (PPE), including gloves and goggles. The compound should be handled in a fume hood due to its reactivity. Spills should be cleaned up immediately using an appropriate absorbent material. This compound should be stored in a cool, dry place. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.