1-(4-fluorophenyl)cyclobutane-1-carbonitrile(CAS: 405090-30-4)

1-(4-fluorophenyl)cyclobutane-1-carbonitrile is a colorless to white crystalline solid with a molecular weight of 198.16 g/mol. It has low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is stable under normal conditions but can react under basic conditions. It has a melting point of 65-67°C and a boiling point of 162-164°C at 10 mmHg.

1-(4-fluorophenyl)cyclobutane-1-carbonitrile can be synthesized by the reaction of 4-fluorophenylacetonitrile with a reducing agent such as sodium borohydride. The reaction typically proceeds with high selectivity and yields around 85-90%. The process involves stirring the mixture under an inert atmosphere and monitoring the reaction progress with TLC or GC.

1-(4-fluorophenyl)cyclobutane-1-carbonitrile is used in the pharmaceutical industry for the synthesis of various drug molecules. It is also utilized in the polymer industry as a monomer for producing functional polymers with specific properties. Additionally, it has applications in the sensor technology for the detection of specific gases and in semiconductor manufacturing for etching processes.

When handling 1-(4-fluorophenyl)cyclobutane-1-carbonitrile, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Avoid inhalation or contact with skin or eyes. In case of a spill, immediately clean up using appropriate waste disposal methods and consult the safety data sheet (SDS) for further instructions. Store the compound in a cool, dry place away from direct sunlight and incompatible materials.