6-Bromo-1-isoquinolinamine(CAS: 215453-26-2)

6-Bromo-1-isoquinolinamine is a white to off-white crystalline solid with a molecular weight of approximately 217.03 g/mol. It is slightly soluble in water and ethanol, but more soluble in organic solvents like dichloromethane. This compound is moderately reactive, especially towards nucleophiles, making it useful in various chemical reactions. Its solubility and reactivity make it suitable for use in synthesis and medicinal chemistry applications.

6-Bromo-1-isoquinolinamine is typically synthesized via a bromination reaction of 1-isoquinolineamine followed by amination. The reaction can be catalyzed by an appropriate catalyst and proceeds with good regioselectivity and yield. The process involves the use of bromine in the presence of a suitable base and solvent, ensuring high efficiency and purity of the final product.

6-Bromo-1-isoquinolinamine is used in the pharmaceutical industry for synthesizing certain drug candidates. It is also utilized in the chemical industry for producing intermediates and in the sensor industry for developing gas detection devices. Its reactivity and specific functional groups make it a valuable compound in these sectors.

When handling 6-Bromo-1-isoquinolinamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS).