1-(4-Pyridinylmethyl)guanidine(CAS: 45957-41-3)

1-(4-Pyridinylmethyl)guanidine (CAS: 45957-41-3) is a white crystalline solid with a molecular weight of approximately 197.21 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). This compound is relatively stable under normal conditions but can react with strong acids or bases. It is used as an intermediate in the synthesis of various pharmaceuticals and is known for its ability to form stable complexes with metal ions.

1-(4-Pyridinylmethyl)guanidine is typically synthesized via the reaction of 4-pyridinemethylamine with guanidine hydrochloride in the presence of a suitable solvent like DMF. The reaction is catalyzed by a mild base and is known for its good yield and high selectivity. The process involves a nucleophilic substitution followed by an amidation reaction, leading to the formation of the desired product.

1-(4-Pyridinylmethyl)guanidine (CAS: 45957-41-3) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of drugs with antiviral and anti-inflammatory properties. It is also utilized in the polymer industry for its ability to enhance the mechanical properties of polymers. Additionally, it finds applications in the development of sensors and as a component in the production of certain semiconductors.

When handling 1-(4-Pyridinylmethyl)guanidine (CAS: 45957-41-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and sources of heat. In case of a spill, it should be cleaned up immediately using appropriate absorbents and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.