1-(4-Aminophenoxy)-3-ethoxy-2-propanol(CAS: 94056-98-1)

1-(4-Aminophenoxy)-3-ethoxy-2-propanol is a colorless liquid with a molecular weight of 245.31 g/mol. It has good solubility in water and organic solvents. The compound is moderately reactive, particularly with bases and reducing agents, and undergoes alcoholysis and nucleophilic substitution reactions. It crystallizes in the orthorhombic system with a specific melting point of 55-56°C.

1-(4-Aminophenoxy)-3-ethoxy-2-propanol can be synthesized via a multi-step process involving the protection of a primary alcohol, followed by nucleophilic substitution with a 4-aminophenol derivative. The reaction is typically catalyzed by a Lewis acid such as zinc chloride, and the yield is around 70-80% with good selectivity. The product is then purified by distillation or recrystallization.

1-(4-Aminophenoxy)-3-ethoxy-2-propanol is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for the production of functionalized polymers, in sensors for its ability to act as a chromophore, and in semiconductor manufacturing for specific etching processes.

When handling 1-(4-Aminophenoxy)-3-ethoxy-2-propanol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Spills should be immediately neutralized with an appropriate base and then cleaned up. Refer to the Safety Data Sheet (SDS) for detailed emergency response procedures and storage conditions to ensure safety during handling and disposal.