methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate(CAS: 1353101-49-1)

Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate is a crystalline solid with a molecular weight of approximately 218.2 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetonitrile. It is not particularly reactive, but it can undergo ester hydrolysis under acidic conditions. This compound has a melting point of around 110-112°C.

Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate can be synthesized by reacting methyl 3-carboxy-1H-pyrrolo[3,2-c]pyridine with a suitable reagent. One common method involves the condensation of methyl 3-carboxy-1H-pyrrolo[3,2-c]pyridine with ethyl chloroacetate in the presence of a base like triethylamine. The yield is generally around 85%, with good selectivity.

Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate is used in pharmaceuticals for the synthesis of certain drug candidates due to its structural complexity. It may also have applications in the development of sensors and semiconductors, although its use in these industries is less well-documented compared to pharmaceuticals.

When handling methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate, it is important to use proper Personal Protective Equipment (PPE), including gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of spill, use appropriate spill cleanup equipment and consult the Safety Data Sheet (SDS) for further instructions. Keep the area well-ventilated, and use a fume hood if necessary.