N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl)acrylamide(CAS: 2414572-47-5)

N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl)acrylamide is a crystalline compound with a molecular weight of approximately 605.16 g/mol. It has low water solubility and is moderately soluble in organic solvents like DMSO. The compound shows moderate reactivity, particularly in the presence of amines and other nucleophiles. It is stable under normal laboratory conditions but should be protected from moisture and air during handling.

N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl)acrylamide is synthesized through a multi-step process involving the coupling of a pyridinylmethoxy moiety with a quinazoline derivative, followed by acrylamidation. The synthesis is catalyzed by a palladium-based catalyst and proceeds under mild conditions. The overall yield is moderate, around 50-60%, and the product is typically isolated by recrystallization from DMSO.

N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl)acrylamide is primarily used in the pharmaceutical industry for its potential as an anticancer agent. It may also find applications in the polymer industry as a functional monomer and in sensor technology due to its specific chemical properties.

When handling N-(4-{[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl)acrylamide, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to laboratory safety guidelines. It is recommended to consult the Safety Data Sheet (SDS) for detailed handling instructions.