2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS: 863868-37-5)

2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a colorless, crystalline solid with a molecular weight of 283.12 g/mol. It has a low solubility in water but is soluble in organic solvents. Chemically, it is highly reactive, particularly in boron-catalyzed reactions.

2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is typically synthesized via a boronation reaction of 2,6-difluorophenylboronic acid with tetramethyl-1,3,2-dioxaborolane in the presence of a palladium catalyst and a base. The reaction is highly selective and yields a high product purity.

2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is primarily used in pharmaceuticals, where it serves as a versatile building block for the synthesis of complex molecules. It is also utilized in the polymer industry for the development of functional polymers and in the semiconductor industry for the fabrication of advanced materials.

When handling 2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work in a well-ventilated area or a fume hood. Follow standard laboratory safety protocols and keep a copy of the Safety Data Sheet (SDS) readily available for reference. Spills should be cleaned up immediately using appropriate materials as outlined in the SDS.