4,4,5,5-Tetramethyl-2-(2-methyl-1-naphthyl)-1,3,2-dioxaborolane(CAS: 312303-48-3)

4,4,5,5-Tetramethyl-2-(2-methyl-1-naphthyl)-1,3,2-dioxaborolane is a white crystalline solid with a molecular weight of approximately 294.34 g/mol. It has a low solubility in water but is soluble in common organic solvents like dichloromethane and toluene. The compound is known for its high reactivity in boron-catalyzed reactions, particularly in Suzuki coupling reactions.

4,4,5,5-Tetramethyl-2-(2-methyl-1-naphthyl)-1,3,2-dioxaborolane is typically synthesized through a multistep process involving the formation of a naphthyl boronic acid, followed by its conversion to the dioxaborolane derivative. This process requires the use of boronic acids, phenol derivatives, and catalysts such as Pd(0) complexes. The yield of the product is around 70-80%.

4,4,5,5-Tetramethyl-2-(2-methyl-1-naphthyl)-1,3,2-dioxaborolane is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various biologically active compounds and is also utilized in the development of novel materials with specific properties.

When handling 4,4,5,5-Tetramethyl-2-(2-methyl-1-naphthyl)-1,3,2-dioxaborolane, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. This compound should be stored in a cool, well-ventilated area, and fume hoods should be used during its manipulation. In case of spill, it should be cleaned up carefully, and the SDS (Safety Data Sheet) should be consulted for detailed guidelines.