(4-Aminophenoxy)acetic acid(CAS: 2298-36-4)

(4-Aminophenoxy)acetic acid is a white to off-white crystalline solid with a molecular weight of approximately 174.17 g/mol. It is sparingly soluble in water and has a pKa of about 2.75. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is also known for its potential in forming salts and esters.

(4-Aminophenoxy)acetic acid can be synthesized by the condensation of phenol and acetic anhydride in the presence of a suitable catalyst, such as p-toluenesulfonic acid. The reaction yield is typically high, and the selectivity for the target product is excellent. The process involves heating the mixture to a specific temperature to promote the reaction and then purifying the product using recrystallization or other chromatographic techniques.

(4-Aminophenoxy)acetic acid is primarily used in the pharmaceutical industry for the synthesis of certain organic compounds and in the production of sensors and semiconductors. It is also utilized in the polymer industry for modifying the properties of polymers and in the development of new materials.

When handling (4-Aminophenoxy)acetic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately with appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.