(2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide(CAS: 1393477-72-9)

This compound is a crystalline solid with a molecular weight of approximately 648.3 g/mol. It has limited solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Chemically, it is highly reactive, particularly towards nucleophiles. It can be used as a key intermediate in various chemical reactions.

This compound is synthesized through a multi-step process involving the coupling of a pyrazinyl acryloyl chloride with 3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}hydrazine. The synthesis typically uses triethylamine as a base and requires the use of a suitable solvent like dichloromethane. The overall yield is moderate, around 50-60%, with excellent selectivity.

This compound is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drug candidates. It also has potential applications in the development of sensors and semiconductors due to its unique chemical structure and reactivity.

When handling this compound, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to airborne particulates. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.