3-Chloro-2-pyrazinecarboxylic acid(CAS: 27398-39-6)

3-Chloro-2-pyrazinecarboxylic acid is a white crystalline solid with a molecular weight of 161.57 g/mol. It is slightly soluble in water and ethanol. Chemically, it is stable under normal conditions but reacts with strong bases to form salts. It is an important intermediate in the synthesis of various organic compounds.

3-Chloro-2-pyrazinecarboxylic acid is commonly synthesized via the chlorination of 2-pyrazinecarboxylic acid. This process involves the reaction of 2-pyrazinecarboxylic acid with thionyl chloride in the presence of a base such as pyridine. The yield is typically around 70-80%, with good selectivity toward the monochlorinated product.

3-Chloro-2-pyrazinecarboxylic acid is widely used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the chemical industry, particularly in the production of herbicides and dyes. Additionally, it is used in the development of sensors and as a component in some polymer formulations.

When handling 3-Chloro-2-pyrazinecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight and incompatible materials. In case of spillage, it should be immediately cleaned up using appropriate spill control materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.