4-Bromo-2-formylbenzoic acid(CAS: 871502-87-3)

4-Bromo-2-formylbenzoic acid is a white crystalline solid with a molecular weight of approximately 229.03 g/mol. It is poorly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards bases and reducing agents. The compound shows carboxylic acid and aldehyde functionalities, making it susceptible to esterification, amide formation, and reduction reactions.

4-Bromo-2-formylbenzoic acid is typically synthesized through the bromination of 2-formylbenzoic acid followed by a protective group modification if necessary. Common methods include using bromine in the presence of a suitable solvent like dichloromethane. The reaction yields a bromo derivative, which can be further functionalized as required. This synthesis involves careful control of reaction conditions to achieve the desired selectivity and yield.

4-Bromo-2-formylbenzoic acid is used in the pharmaceutical industry for the synthesis of certain drug intermediates due to its functional groups. It also finds applications in the polymer industry for the development of specific monomers. In the semiconductor industry, it can be used in the synthesis of photoresists and other materials. Additionally, it has potential use in the sensing applications where its chemical reactivity can be exploited.

When handling 4-Bromo-2-formylbenzoic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. Due to its reactivity, it should be used in a well-ventilated area or a fume hood. In case of a spill, it should be cleaned up using appropriate absorbent materials and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.