2-(4-Morpholinyl)aniline(CAS: 5585-33-1)

2-(4-Morpholinyl)aniline (CAS: 5585-33-1) is a white crystalline solid with a molecular weight of 215.31 g/mol. It has a pKa of 8.7 and is moderately soluble in water. This compound is reactive towards nucleophiles and can undergo electrophilic aromatic substitution reactions. It has a distinctive amine smell and is commonly used in organic synthesis and as a precursor in various chemical processes.

2-(4-Morpholinyl)aniline is typically synthesized via the diazotization of 4-morpholino-N-nitrosoaniline followed by reduction. The process involves the use of nitrous acid or sodium nitrite in a suitable solvent. The reaction is highly exothermic and requires careful temperature control to avoid decomposition. The yield of the product is generally around 80-90%. Other methods include the coupling of 4-morpholinyl chloride with aniline under mild conditions, yielding a high purity product.

2-(4-Morpholinyl)aniline (CAS: 5585-33-1) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and therapeutic agents. Additionally, it is utilized in the production of dyes, coatings, and as a stabilizer in semiconductor materials. Its role in sensors and as a component in some electronic devices is also recognized.

When handling 2-(4-Morpholinyl)aniline (CAS: 5585-33-1), it is crucial to follow standard safety protocols. Wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation. Dispose of any waste according to local regulations and maintain a safety data sheet (SDS) for reference. In case of a spill, neutralize the acid or base as appropriate and clean the area thoroughly.