N-Biotinylcaproylaminocaproic Acid(CAS: 89889-51-0)

N-Biotinylcaproylaminocaproic Acid is a solid with a crystalline form. Its molecular weight is approximately 562.4 g/mol. It has low solubility in water but good solubility in organic solvents such as DMSO and acetonitrile. The compound is moderately reactive, particularly towards nucleophiles and bases. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

N-Biotinylcaproylaminocaproic Acid is synthesized via a multi-step process. Commonly, it involves the coupling of biotin to caproylaminocaproic acid using a carbodiimide coupling agent, such as EDAC. The reaction is typically carried out in the presence of a water-miscible solvent like DMF, with good yield and high selectivity. The product is then purified by column chromatography or recrystallization.

N-Biotinylcaproylaminocaproic Acid is primarily used in pharmaceuticals for drug conjugation and in biotechnology for immobilizing biomolecules. It is also utilized in the polymer industry for modifying surfaces and in the semiconductor industry for functionalizing substrates. Additionally, it can be found in sensor technology for biofunctionalization applications.

When handling N-Biotinylcaproylaminocaproic Acid, proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The compound should be handled in a fume hood due to its reactivity. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Safety data sheets (SDS) should be consulted for detailed safety information and emergency procedures. Storage should be in a cool, dry place away from direct sunlight and heat sources.