2-(5-Amino-2-pyridinyl)-2-methylpropanenitrile(CAS: 1226776-95-9)

2-(5-Amino-2-pyridinyl)-2-methylpropanenitrile is a crystalline solid with a molecular weight of approximately 233.27 g/mol. It has moderate solubility in common organic solvents like ethanol and acetone. The compound is relatively stable under normal laboratory conditions but can react with strong acids and bases. It is not flammable but should be stored in a dry environment to prevent hydrolysis.

2-(5-Amino-2-pyridinyl)-2-methylpropanenitrile can be synthesized via a multi-step process, starting with pyridine and methyl acrylate. The key steps include alkylation and amidation. Commonly, this involves the reaction of 2-methylacrylonitrile with 5-amino-2-pyridine carboxylic acid in the presence of a catalyst such as triethylamine. The yield is typically around 75-85%, with good selectivity towards the target product.

2-(5-Amino-2-pyridinyl)-2-methylpropanenitrile is primarily used in pharmaceuticals for its role as a precursor in the synthesis of antitumor drugs. It also has applications in the sensor industry due to its ability to interact with certain metal ions and other analytes, making it useful for detection and analysis purposes.

When handling 2-(5-Amino-2-pyridinyl)-2-methylpropanenitrile, it is important to use personal protective equipment (PPE) such as goggles, gloves, and a lab coat. It should be stored in a well-ventilated area to avoid inhalation and should be handled in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate chemical spill kits. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and emergency procedures.