5-(Trifluoromethyl)-2-furaldehyde(CAS: 17515-80-9)

5-(Trifluoromethyl)-2-furaldehyde (CAS: 17515-80-9) is a colorless to light yellow liquid with a molecular weight of 177.07 g/mol. It has a high boiling point of 193-194°C and a density of 1.43 g/mL. It is slightly soluble in water but highly soluble in organic solvents. The compound is known for its high reactivity, particularly towards nucleophiles and reducing agents.

5-(Trifluoromethyl)-2-furaldehyde (CAS: 17515-80-9) is typically synthesized by the trifluoroacetylation of furfural using triflic anhydride as a catalyst. The reaction involves the formation of an intermediate triflate ester, which then undergoes nucleophilic attack to form the final aldehyde. The yield of the reaction can be up to 85%, and the product is usually obtained with high selectivity.

5-(Trifluoromethyl)-2-furaldehyde (CAS: 17515-80-9) is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and as a precursor in the production of polymers and sensors. It is also utilized in the semiconductor industry for specific applications.

When handling 5-(Trifluoromethyl)-2-furaldehyde (CAS: 17515-80-9), it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and chemical-resistant clothing. Work should be carried out in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up using suitable absorbents and disposed of according to local regulations. Always consult the safety data sheet (SDS) for detailed safety information.