(3S)-3-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-pyrrolidinone(CAS: 130403-91-7)

(3S)-3-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-pyrrolidinone (CAS: 130403-91-7) is a colorless to white crystalline solid with a molecular weight of approximately 286.4 g/mol. It has low water solubility and moderate solubility in organic solvents like methanol and acetonitrile. Chemically, it is highly reactive towards nucleophiles and can undergo various transformations under specific conditions, such as hydrolysis or silyl group displacement.

(3S)-3-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-pyrrolidinone is usually synthesized via a silylation reaction of the corresponding pyrrolidone with dimethyl(2-methyl-2-propanyl)silane in the presence of a base, such as triethylamine. The reaction is typically carried out in an aprotic solvent like tetrahydrofuran (THF) at low temperature to achieve high yield and selectivity.

(3S)-3-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-pyrrolidinone (CAS: 130403-91-7) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drug compounds. It is also utilized in the polymer industry for modifying the chemical properties of polymers, and in the semiconductor industry for its use in organic light-emitting diodes (OLEDs) due to its electron-donating properties.

Precautions when handling (3S)-3-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-pyrrolidinone (CAS: 130403-91-7) include wearing appropriate personal protective equipment (PPE), such as lab coats, gloves, and safety goggles. The substance should be handled in a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed safety and handling instructions.