[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid(CAS: 850568-05-7)

[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid (CAS: 850568-05-7) is a white to off-white crystalline solid with a molecular weight of approximately 266.2 g/mol. It is slightly soluble in water and has good solubility in organic solvents like EtOH and DMSO. The compound is known for its reactivity in boronate ester formation and is often used in organic synthesis. It has a melting point of around 125-127°C.

[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid (CAS: 850568-05-7) is typically synthesized through a multi-step process involving the preparation of 5-fluoro-2-(methoxycarbonyl)phenol followed by Mitsunobu reaction with boronic acid. Common catalysts include triphenylphosphine and diisopropyl azodicarboxylate. The yield is generally around 70-80%, and the product is purified by recrystallization or column chromatography.

[5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid (CAS: 850568-05-7) is primarily used in the pharmaceutical and chemical industries due to its reactivity in boronate ester formation. It finds application in the synthesis of pharmaceuticals, materials, and organic compounds. This compound is also used in research for developing new drugs and materials with specific functional groups.

When handling [5-Fluoro-2-(methoxycarbonyl)phenyl]boronic acid (CAS: 850568-05-7), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, immediately clean up the area using appropriate methods and refer to the Safety Data Sheet (SDS) for specific handling procedures. Ensure that all reactions involving this compound are conducted in a well-ventilated fume hood to minimize exposure and inhalation risks.