2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid(CAS: 7303-50-6)

2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid is a white crystalline solid with a molecular weight of approximately 249.23 g/mol. It has a pKa of around 4.0 and is moderately soluble in water. The compound shows good reactivity in acid or base catalysis, making it suitable for various chemical reactions. It is also stable under normal laboratory conditions but requires protection from strong bases and oxidizing agents.

2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid can be synthesized using a multi-step process involving the condensation of 3-(1H-pyrrolo[2,3-b]pyridin-3-yl)acetyl chloride with an amino alcohol. The reaction is typically performed under mild conditions, and the product is isolated through crystallization. The synthesis usually yields a purity of over 95%, with good selectivity and yield.

2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid finds applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of anti-inflammatory and antiviral drugs. It is also utilized in the polymer industry as a monomer for the production of advanced materials. Additionally, it has potential uses in sensor technology and semiconductor processing due to its unique chemical properties.

When handling 2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to prevent inhalation exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. For further safety information, consult the material safety data sheet (MSDS) for detailed procedures.