5-Formyl-2-hydroxybenzonitrile(CAS: 73289-79-9)

5-Formyl-2-hydroxybenzonitrile is a white to off-white crystalline solid with a molecular weight of approximately 204.15 g/mol. It is slightly soluble in water but more soluble in polar organic solvents like ethanol and acetone. The compound is moderately reactive, showing electrophilic character, and can undergo nucleophilic substitution and condensation reactions.

5-Formyl-2-hydroxybenzonitrile is typically synthesized via a multistep process involving the reaction of 2-hydroxybenzonitrile with formic acid under mild conditions. This reaction involves esterification followed by hydrolysis to yield the desired product. Commonly used conditions include the presence of a catalyst like sulfuric acid and heating under reflux.

5-Formyl-2-hydroxybenzonitrile finds applications in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the production of functionalized polymers. Additionally, it has potential uses in the development of sensors and semiconductors due to its chemical reactivity and ability to form stable complexes.

When handling 5-Formyl-2-hydroxybenzonitrile, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood due to its chemical reactivity. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local hazardous waste regulations. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.