2-(1-Piperidinyl)nicotinic acid(CAS: 78253-61-9)

2-(1-Piperidinyl)nicotinic acid is a crystalline solid with a molecular weight of approximately 224.28 g/mol. It has a solubility of about 1.2 g/L in water at 25°C. The compound is moderately reactive, particularly towards bases, and forms hydrogen bonds in its crystalline form. It is mildly acidic and can undergo esterification reactions under certain conditions.

2-(1-Piperidinyl)nicotinic acid is typically synthesized by reacting piperidine with nicotinic acid in the presence of a mild base like triethylamine. The reaction involves the substitution of the amide group of nicotinic acid by the piperidine ring. The process yields a pure product with good selectivity and a yield of around 70-80%.

2-(1-Piperidinyl)nicotinic acid is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also employed in the polymer industry as a plasticizer and in the electronics industry as a component in the fabrication of sensors and semiconductors.

When handling 2-(1-Piperidinyl)nicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate spill kits. Proper storage in a cool, dry place away from heat sources is recommended. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.