1-(4-Fluorophenyl)-4-piperidinone(CAS: 116247-98-4)

1-(4-Fluorophenyl)-4-piperidinone (CAS: 116247-98-4) is a white to off-white crystalline solid with a molecular weight of approximately 223.22 g/mol. It is slightly soluble in water and soluble in organic solvents like ethanol and DMSO. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It is a useful intermediate in pharmaceutical and chemical synthesis.

1-(4-Fluorophenyl)-4-piperidinone can be synthesized via a direct fluorination of 1-(4-hydroxyphenyl)-4-piperidinone or through amination of 4-fluorophenol followed by oxidation. Commonly, this involves the use of trifluoroacetic anhydride or other fluorinating agents. The reaction typically provides good yield with high selectivity.

1-(4-Fluorophenyl)-4-piperidinone (CAS: 116247-98-4) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical compounds. It is also explored in polymer chemistry for its potential in the development of advanced materials and in sensor technology for its chemical reactivity.

When handling 1-(4-Fluorophenyl)-4-piperidinone (CAS: 116247-98-4), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be handled in a fume hood, and proper waste disposal procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed safety information.