1-[(Benzyloxy)carbonyl]-4-oxo-L-proline(CAS: 64187-47-9)

1-[(Benzyloxy)carbonyl]-4-oxo-L-proline is a white crystalline solid with a molecular weight of approximately 274.27 g/mol. It is slightly soluble in water and has good solubility in organic solvents like methanol and ethanol. Chemically, it exhibits moderate reactivity, particularly in ester and amide bond formation, and it is stable under normal storage conditions.

1-[(Benzyloxy)carbonyl]-4-oxo-L-proline can be synthesized via the condensation of benzyloxycarbonyl chloride with L-proline, followed by dehydration. Commonly, this reaction is performed in the presence of a base such as triethylamine. The overall yield is typically around 75-85%, and the reaction is selective for the desired product.

1-[(Benzyloxy)carbonyl]-4-oxo-L-proline is primarily used in the pharmaceutical industry for the synthesis of various prodrugs and peptide-based drugs. It is also used in the polymer industry for the modification of polymer chains, and in the sensor and semiconductor industries for the development of new materials and devices.

When handling 1-[(Benzyloxy)carbonyl]-4-oxo-L-proline, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety glasses. The material should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbent materials, and the material safety data sheet (SDS) should be consulted for specific handling and disposal procedures.