1-(5-Methyl-1,3,4-oxadiazol-2-yl)methanamine(CAS: 125295-22-9)

1-(5-Methyl-1,3,4-oxadiazol-2-yl)methanamine (CAS: 125295-22-9) is a crystalline solid with a molecular weight of approximately 166.21 g/mol. It has a pKa of about 6.9 and a solubility of 0.15 g/100 mL in water. This compound exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It is stable under normal laboratory conditions but should be stored in airtight containers to prevent moisture absorption.

1-(5-Methyl-1,3,4-oxadiazol-2-yl)methanamine can be synthesized via the reaction of methyl isocyanate with 5-methyl-1,3,4-oxadiazole. Commonly, this is achieved using phosgene as a catalyst, leading to a high yield of the desired product. The reaction is performed under anhydrous conditions to enhance selectivity and yield. Proper handling of phosgene is essential to prevent unwanted side reactions.

1-(5-Methyl-1,3,4-oxadiazol-2-yl)methanamine (CAS: 125295-22-9) has applications in the pharmaceutical and polymer industries. It serves as a precursor in the synthesis of various pharmaceutical intermediates and plays a role in the development of advanced polymers with improved properties. Additionally, this compound is used in the production of sensors and semiconductors due to its unique chemical structure.

When handling 1-(5-Methyl-1,3,4-oxadiazol-2-yl)methanamine (CAS: 125295-22-9), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle this compound in a well-ventilated environment or under a fume hood to minimize exposure. In case of a spill, immediately clean it up using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal. Storage should be in a cool, dry place, away from direct sunlight and sources of heat.