(3aR,7aR)-Hexahydro-2-benzofuran-1,3-dione(CAS: 71749-03-6)

(3aR,7aR)-Hexahydro-2-benzofuran-1,3-dione is a white crystalline solid with a molecular weight of approximately 194.24 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. The compound is known for its reactive nature, particularly in nucleophilic substitution and electrophilic addition reactions.

(3aR,7aR)-Hexahydro-2-benzofuran-1,3-dione can be synthesized via the condensation of 2-benzofuran-1,3-dione with an appropriate aldehyde in the presence of a catalyst such as hydroxylamine hydrochloride. This process yields the compound with good selectivity and moderate to high yield depending on the reaction conditions.

(3aR,7aR)-Hexahydro-2-benzofuran-1,3-dione is mainly used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also has applications in the polymer and sensor industries as a precursor for functional materials and in the semiconductor industry for its unique chemical and physical properties.

When handling (3aR,7aR)-Hexahydro-2-benzofuran-1,3-dione, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the material safety data sheet (MSDS) should be consulted for detailed spill cleanup procedures.