Imidazo[1,2-a]pyridin-8-amine(CAS: 73221-18-8)

Imidazo[1,2-a]pyridin-8-amine is a solid with high crystallinity. Its molecular weight is approximately 193.25 g/mol. This compound is poorly soluble in water but soluble in common organic solvents like DMSO and DMF. It exhibits moderate reactivity with basic compounds, making it suitable for forming amine adducts. It is stable under normal storage conditions but should be protected from moisture.

Imidazo[1,2-a]pyridin-8-amine can be synthesized through the condensation of 8-amino-1H-imidazo[1,2-a]pyridine with appropriate reagents under basic conditions. Common methods include the use of sodium hydride as a base. The reaction is typically carried out in solvents like DMF or DMSO. The yield is good, and the product is isolated by column chromatography.

Imidazo[1,2-a]pyridin-8-amine is primarily used in the pharmaceutical industry, particularly in the development of antiviral and anticancer drugs. It also finds applications in the synthesis of semiconductors and as a sensor component in chemical and biological detection systems. Its structural properties make it valuable for polymer chemistry as well.

When handling Imidazo[1,2-a]pyridin-8-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood. Store the compound in a dry and cool place, away from moisture. In case of a spill, clean up with caution and consult a Material Safety Data Sheet (MSDS) for further guidance. Avoid skin contact and ingestion.