5-Bromo-6-fluoronicotinic acid(CAS: 29241-63-2)

5-Bromo-6-fluoronicotinic acid is a crystalline compound with a molecular weight of approximately 213.03 g/mol. It has a solubility of about 0.13 g/100 mL in water. This compound is reactive towards nucleophiles and can undergo substitution reactions. It is also acidic and can form salts with bases.

5-Bromo-6-fluoronicotinic acid is commonly synthesized through the bromination of 6-fluoronicotinic acid followed by an intermolecular Friedel-Crafts acylation. The reaction typically requires a Lewis acid catalyst such as aluminum chloride. The yield is generally around 70-80%, and the process requires careful control of temperature and reaction time to achieve high purity.

5-Bromo-6-fluoronicotinic acid is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various drugs, particularly those targeting the nervous system. Additionally, it finds applications in the development of sensors and as a reagent in academic research for studying organic transformations.

When handling 5-Bromo-6-fluoronicotinic acid, it is essential to wear appropriate personal protective equipment (PPE) such as chemical-resistant gloves, safety goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to minimize exposure to the fumes. Proper spill disposal procedures should be followed, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.