Methyl 6-bromo-2-pyrazinecarboxylate(CAS: 40155-34-8)

Methyl 6-bromo-2-pyrazinecarboxylate is a crystalline solid with a molecular weight of approximately 250.03 g/mol. It is slightly soluble in water but readily soluble in organic solvents like methanol and ethanol. Chemically, it is moderately reactive towards nucleophiles and is commonly used in organic synthesis. It has a melting point around 75-77°C.

Methyl 6-bromo-2-pyrazinecarboxylate can be synthesized through the bromination of methyl 2-pyrazinecarboxylate using N-bromosuccinimide (NBS) in the presence of a radical initiator. This method provides good yield and selectivity for the bromo substituent at the 6-position. Common solvents include dichloromethane or acetonitrile.

Methyl 6-bromo-2-pyrazinecarboxylate is primarily used in the pharmaceutical industry for the synthesis of various biologically active compounds. It also finds applications in polymer chemistry for functionalizing polymers and in sensor technology for detecting specific chemical species.

When handling Methyl 6-bromo-2-pyrazinecarboxylate, it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. Work in a well-ventilated area or a fume hood to avoid inhalation of the compound. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.