5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine(CAS: 1214377-42-0)

5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 315.03 g/mol. It is slightly soluble in water but readily soluble in organic solvents like ethanol and acetone. This compound is known for its high reactivity due to the presence of bromine, methoxy, and trifluoromethyl groups, making it suitable for various synthetic applications and transformations.

5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine is usually synthesized via the bromination of 2-methoxy-3-(trifluoromethyl)pyridine with N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The reaction yields a mixture that can be purified by recrystallization or column chromatography, with good selectivity and yield under optimized conditions.

5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine finds applications in pharmaceuticals, where it serves as a precursor for various medicinal compounds. It is also used in the synthesis of polymers, sensors, and semiconductor materials for its unique electronic properties and functional groups.

When handling 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. In case of spillage, neutralize the spill with a suitable absorbent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.