6-amino-2H-1,4-benzoxazin-3(4H)-one(CAS: 89976-75-0)

6-Amino-2H-1,4-benzoxazin-3(4H)-one (CAS: 89976-75-0) is a white to off-white crystalline solid with a molecular weight of approximately 193.21 g/mol. It is slightly soluble in water and acetone. The compound is known for its reactivity, particularly in nucleophilic aromatic substitution reactions. It has low volatility and is stable under normal conditions.

6-Amino-2H-1,4-benzoxazin-3(4H)-one (CAS: 89976-75-0) can be synthesized through the condensation of a benzaldehyde derivative with an isoxazole in the presence of a strong base, such as sodium hydride. The reaction is typically carried out in a solvent like N-methyl-2-pyrrolidone (NMP) at room temperature. The yield is usually around 70-80%, and the compound is isolated by recrystallization.

6-Amino-2H-1,4-benzoxazin-3(4H)-one (CAS: 89976-75-0) is used in various industries. It is particularly important in the pharmaceutical sector for its potential as an intermediate in drug synthesis. It is also used in the production of polymers and as a sensor material due to its unique chemical properties.

When handling 6-amino-2H-1,4-benzoxazin-3(4H)-one (CAS: 89976-75-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with caution, using appropriate absorbent materials, and the area should be cleaned thoroughly. Always consult the Safety Data Sheet (SDS) for detailed safety information and procedures.