3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine(CAS: 944401-75-6)

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine is a white crystalline solid with a molecular weight of approximately 302.3 g/mol. It has a solubility of up to 2.5% in water and poor solubility in common organic solvents. The compound is chemically stable under normal conditions but can react with strong acids or bases.

This compound is typically synthesized via a palladium-catalyzed coupling reaction between a fluoro-pyridinamine and a boronic acid derivative. The reaction is carried out in the presence of a base such as sodium carbonate and a palladium(II) acetate catalyst. The yield is usually around 70-80%, with high regioselectivity and good purity.

This compound is used in pharmaceutical research for the synthesis of drug candidates. It also finds applications in the polymer industry as a building block for functional polymers. Additionally, it is of interest in analytical chemistry for use in sensors and in the electronics industry for semiconductor applications.

When handling this compound, proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from strong acids, bases, and oxidizers. In case of spillage, use appropriate spill kits and ensure proper disposal according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed guidelines.