21-Deoxyprednisolone(CAS: 20423-99-8)

21-Deoxyprednisolone is an anti-inflammatory corticosteroid. It is a white or off-white crystalline powder with a strong steroid odor. The molecular formula is C21H26O5, and the molecular weight is approximately 358.44 g/mol. It has low water solubility and is soluble in methanol and acetone. It is relatively stable under normal conditions but reacts with bases and oxidizing agents.

21-Deoxyprednisolone is synthesized from 21-hydroxyprednisolone using a deoxygenation process. The common method involves treating 21-hydroxyprednisolone with an acid catalyst at elevated temperatures. This process selectively removes the hydroxyl group at position 21, yielding 21-deoxyprednisolone. The yield is typically around 80-90%, and the selectivity is high.

21-Deoxyprednisolone is primarily used in the pharmaceutical industry as a raw material for the synthesis of corticosteroid drugs. It is also used in the research and development of new drugs and in the production of corticosteroid-based medicaments for treating inflammation and immune-related diseases. Additionally, it has applications in agriculture and veterinary medicine for treating inflammation and endoparasites.

When handling 21-Deoxyprednisolone, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust. Spills should be immediately cleaned up using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.