1-Methyl-1H-pyrrole-2-carbonitrile(CAS: 34884-10-1)

1-Methyl-1H-pyrrole-2-carbonitrile is a colorless liquid with a molecular weight of approximately 118.12 g/mol. It has a high boiling point of around 180°C and a low melting point of -12°C. The compound is moderately soluble in water but highly soluble in organic solvents like dimethylformamide. It is known for its moderate reactivity, particularly towards nucleophilic and electrophilic reactions.

1-Methyl-1H-pyrrole-2-carbonitrile can be synthesized through the reaction of methyl acrylate with hydrogen cyanide in the presence of a base such as sodium hydroxide. The reaction is typically carried out in a solvent like dimethylformamide, and yields are generally good with high selectivity for the desired product.

1-Methyl-1H-pyrrole-2-carbonitrile finds applications in various industries, including pharmaceuticals, where it is used as a precursor in the synthesis of certain drug molecules. It is also utilized in the polymer industry for modifying polymer properties, and in the semiconductor industry as a precursor in the fabrication of organic semiconductors. Additionally, it is used in the development of gas sensors due to its reactivity.

When handling 1-Methyl-1H-pyrrole-2-carbonitrile, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.