(2-Aminophenyl)boronic acid hydrochloride (1:1)(CAS: 863753-30-4)

(2-Aminophenyl)boronic acid hydrochloride is a white crystalline powder with a molecular weight of approximately 243.13 g/mol. It is slightly soluble in water and ethanol. Reactivity is moderate towards nucleophiles, making it useful in various organic reactions. The hydrochloride salt form enhances its solubility in aqueous media and is often used in synthetic chemistry and biological applications.

(2-Aminophenyl)boronic acid hydrochloride can be synthesized through the reaction of 2-aminophenol with boron trifluoride in the presence of an acid catalyst, such as hydrochloric acid, followed by the addition of water to form the hydrochloride salt. The reaction is performed under mild conditions, and the yield is typically around 70-80%. This method is widely used in the preparation of boronic acid derivatives for various applications.

(2-Aminophenyl)boronic acid hydrochloride is utilized in multiple industries, including pharmaceuticals for drug synthesis, polymers for functional materials, sensors for detection purposes, and semiconductors for electronic devices. Its reactivity and solubility make it a valuable intermediate in organic synthesis and material science.

When handling (2-Aminophenyl)boronic acid hydrochloride, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and proper disposal methods. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.