2-Amino-4-nitrobenzonitrile(CAS: 87376-25-8)

2-Amino-4-nitrobenzonitrile is a crystalline solid with a molecular weight of approximately 224.12 g/mol. It has a solubility of about 1.5 g/100 mL in water and is sparingly soluble in polar solvents. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions.

2-Amino-4-nitrobenzonitrile can be synthesized by reacting 4-nitrobenzonitrile with ammonia in the presence of a catalyst such as cupric oxide (CuO). The reaction involves a nucleophilic aromatic substitution at the amino position, with good yield and selectivity.

2-Amino-4-nitrobenzonitrile is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the production of dyes and intermediates for the polymer and semiconductor industries.

When handling 2-Amino-4-nitrobenzonitrile, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be performed in a fume hood to minimize inhalation risks. In case of a spill, immediate action should be taken to clean up the area and refer to the safety data sheet (SDS) for detailed instructions.